Windows

  • sociagami — sociagami allows you to manage your multiple social network statuses from one beautiful Windows application. sociagami currently supports Myspace, Facebook, and Twitter status.
  • chirpscreen - chirpscreen, is a screen saver that displays content from your friends - starting with your friends’ photos and status messages from Facebook, Flickr and now Twitter.
  • (http://www.twitterlights.com)- The easiest way to highlight web snippets and Twitter them. i-Lighter+Twitter=Twitterlights! and it’s free!
  • OutTwit - OutTwit (Outlook + Twitter = OutTwit) Use Twitter from Outlook.
  • TwitBOX - The *BEST* Twitter Windows Client out there.
  • Twitter Şeyi (Update) — Twitter Şeyi developed on .NET 2.0 with C# and is a open source software by Oguzhan
  • Twitterlicious — Twitterlicious is a small app that makes using Twitter more fun. It handles all the hard work, leaving you to read and write tweets with the minimum fuss. Best of all, *Twitterlicious is free*!
  • Twitterlights — Twitterlights is an integrated feature of i-Lighter 2.1 allowing one-click tweeting and content saving with your mouse — all free!
  • Pwytter - Free open source Twitter client written in Python by PJ Coudert. User Interface in 14 languages.
  • TwittMe! - A new Twitter Windows Client 1.0.4. Updates itself directly without user input, keeping it always as bug free as possible. Will open source it when client it’s more feature complete.
  • TeleTwitter - A Windows Twitter application that tries hard to be simple and beautiful, like it’s web 2.0 name sake.
  • Twitter Gadget - A Windows Vista Desktop Sidebar Gadget that helps you keep track of all the sweet tweets! Fetches tweets from twitter.com and updates them every 10 seconds.
  • Twitter-Sync (Yahoo Messenger Plugin) - Keeps your Yahoo! Messenger status and Twitter in synchronization. Update your Yahoo! Status to create a new tweet. Your new tweets update your Yahoo! status. Also keeps track of your twitter friends from the main messenger window with alerts, pop-ups + more… — by WackyB.
  • Twitter Desktop - A How-To for making TwitterVision your desktop background, watch live tweets while working.(not an app)
  • TwittIt - A system tray application for easy posting to Twitter by Denis Briel
  • Twitter CLI - Easy to use Command Line Interface allows submitting tweets to Twitter from the Windows CMD Prompt or ‘Run’ box — by Jason Fowler.
  • KlipFolio - World’s smallest personal dashboard to track Twitter Updates, with instant notifications.
  • TwitterYM - a tiny ruby script that updates your Yahoo Messenger status with your latest Twitter one (requires Windows and Ruby) - by Alex Brie
  • Twadget - A Windows Vista sidebar gadget by Rod Begbie
  • TwApp! for Windows — by Harper Reed (Requires .NET 2.0)
  • TWTSUB14.zip Twitter Submitter W32 1.4 now available. For Windows 95/98/2k/XP (tested) Submit Twitterings to Twitter.com without using a web browser! Submit Private messages as well! (D username message)Kenneth Udut (simplify3@aol.com)
  • twtview.zip | Twtview 1.4 NEW FEATURES: ‘pm’ lets you see your private messages, ‘u twittername’ will show any public users homepage. (Jan 27 07). For Win32. View all public timelines and personal timeline without needing web browser. Can be used at the same time as Twitter Submitter W32 to instantly see your submissions. Kenneth Udut
  • Twitteroo 1.4 for Windows released on 13 March 07 (by RareEdge Design Group) - *new* features include font resizing, transparency, sound notifications, built-in URL shortening. Programmable API!
  • Twidget for Konfabulator/ Yahoo! Widgets Post from your desktop.
  • Twessenger — a Twitter add-in for Windows Live Messenger 8.1. Sets your personal message to your latest tweet! — by Kunal Kundaje
  • Visual Twit — a simple Twitter posting client for Windows — by Andy
  • triQQr — Twitter Client for Windows v0.2 with posting, profiles, direct messages and link to homepage of user
  • Chirrup — a simple Windows client for Japanese
  • Twitterbox — Twitter client for Windows made with beon widget technology.
  • MadTwitter — a clon of Twitterrific for Windows which doesn’t require .NET — by Sacha Fuentes
  • Flotzam — A Mash Up of Twitter, Flickr, Facebook and blogs, completely configurable — by Karsten Januszewski and Tim Aidlin
  • Twit4Live — A Messenger Plus! Live Script that adds twitter interaction to Windows Live Messenger
  • Witty — A Twitter client for Windows Vista and XP powered by the Windows Presentation Foundation (WPF) by Alan Le
  • QckTwit — A simple Twitter app that you can activate anytime by Shift+Alt+T and it would pop up presenting a text box to enter your update quickly. As soon as you press Ctrl+Enter, it will send update to Twitter and get out of your way. Separate box for URL. If your message exceeds Twitter’s limit then it will automatically break it down in multiple twits and color those extra chars differently. Open source, requires .Net 3.5 — by Shital Shah
  • JabberTwitterBridge — A java application which check your Jabber or google talk (gtalk) status and update your Twitter status if there is a new one. MrCba

Mac

Linux

  • ktwitter - A simple Twitter script for KDE.
  • twitter.el Twitter from Emacs!
  • twit.el Another Emacs client.
  • Vim Twitter Twitter from Vim!
  • gTwitter — a Twitter client for Linux.
  • GtkTwitter — a Twitter client for Linux and Windows which using GTK.
  • Twitbar — a Twitter client for Gnome users to post from the Deskbar
  • Twit and Wayd — Two addons for Gnome Deskbar that allow posting updates to Twitter
  • BLT — twitter meets the Bourne shell, with a hint of biff.
  • Twitux — a Twitter client for the Gnome desktop. Features includes: gui-notifications, url tinyzer, and more..
  • ZenTwitter — bash script which uses zenity and curl (could be launched from custom desktop/menu/panel icons)
  • mitter — A very simple Python and pygtk client.

Multi Platform

  • TwitKit Integrate Twitter into your Firefox browsing experience.
  • TwitterBack Sync and befriend all of your followers.
  • Post to Twitter from Vim for Vim users.
  • Shareaholic for Firefox. Post URL/webpage related tweets from within your browser.
  • Twitter Opera widget A widget for the Opera browser.
  • TTYtter An interactive text-mode Twitter client, with full background asynchronous updates, written in Perl 5. Requires curl or Lynx, but no additional Perl modules. Tested on Mac OS X, NetBSD, AIX and other Unix-like OSes. Includes full API and a “bot” daemon mode.
  • Nitwit, the cross-platform microblogging client for Twitter, Jaiku and other platforms including Jabber and IRC. Written in PHP-GTK.
  • Tweetr one of the best twitter desktop applications, drag and drop file transfer, send webcam photos instantly, view replies and direct messages, very clean user interface.
  • twitterAIR — An AIR (Adobe Integrated Runtime) application built with Flex 3 that lets you view your friends and public timeline, post your status, and determine the auto-refresh interval.
  • Mugshot for Windows and Linux — show friends’ updates from your favorite services, including Twitter, on your desktop and the web
  • Spaz — An attractive, powerful Twitter client for Windows and OS X using the AIR platform. Direct messaging, deleting tweets, user management, and powerful skinning/theming via CSS.
  • Twitterbot — A simple bot written in C# (Mono/.NET) to reformat RSS feeds of news/sports/etc for Twitter
  • Twerp — A simple command-line tool to post messages and download your friend’s timeline. Python 2.4 or 2.5.
  • PhotoTwitter. This application allows you to take a Snapshot using your Webcam and post the photo and your text on Twitter. Initially written for Mac but could also work on other platforms. Please let me know about problems on non-Mac platforms.
  • Twitter4Skype — Instructions on how to access your Twitter account in Skype. Developer here.
  • Tweeter — A Java desktop client for Twitter a-la Twitteroo but with proxy support. Lets you update your status and follow the public/ ‘with friends’ timelines, view images on the timeline, add/ remove friends, send direct messages, notifications on friends timeline update, minor GUI customization. ( Built with the jTwitter API from ThinkTank )

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  • Twinja AIR — Twinja! A sleek black Twitter client built in Flash, running on AIR. Allows you to communicate with your Twitter friends directly from your desktop. Works on both Mac & PC.
  • Snitter — lots of features with a great UI make this Twitter client stand out from the crowd. Built on AIR.
  • twhirl — A multi-account Twitter desktop client based on AIR and Flex. Compact UI, keyboard shortcuts, many features like auto-connect, auto-refreshing tweets, sending updates, replies, direct messages and more
  • twibble — A twitter desktop client with a clear UI. Supports multi accounts, iTunes like cover flow view and much more. Built on Adobe AIR for Mac and PC.
  • Posty - A microblogging application which allows to post the same message with one click to twitter, jaiku, pownce and tumblr. Posty also includes browsing of personal and public notes, plus the ability to post replies in Twitter and Pownce. Posty is an Adobe Air application which runs on Windows and MacOsx.
  • Twitch - A cross platform Twitter client written using Adobe Air. Twitch focusses on having a clean and simple user interface.

Second Life

  • TwitterBox — a Twitter client for Second Life.
  • SLTweets.com — a Twitter HUD for Second Life, includes mapping, notes, research, SLURL logs. On or off modes.
  • TinySL.com — a Second Life specific SLURL builder and long SLURL or Second Life compression too so Twitter users know the content is relevant or an in-world (metaverse) destination.
  • Squawk — A Twitter client for Second Life. Also supports Ma.gnolia, del.icio.us and Jaiku. Integrates with Squawknest, a web component with user profiles, tagging and web maps.
  • Sl-Messenger.com - A global IM/twitter/diary service for Second Life.

Other

Preliminary list gathered from the Twitter Fan Wiki